Electronic line calling technology was also deployed at the Australian Open, a move largely welcomed by players.
In her first match since winning the Australian Open, women's world number two Naomi Osaka beat Ajla Tomljanovic 7-6 (7/3), 6-4.
Djokovic tied Rafael Nadal’s record by earning his 35th title at a Masters 1000 tournament, overcoming a sluggish start to beat Milos Raonic 1-6, 6-3, 6-4 in the Western & Southern Open final and improve to 23-0 this season.
Bianca Andreescu upset three-time major champion Angelique Kerber 6-4, 3-6, 6-4 to win the BNP Paribas Open, becoming at age 18 the first wild-card winner in tournament history.
The two-time Grand Slam winner, currently ranked 128th in the world, defeated 44th-ranked Donna Vekic 4-6, 7-6 (9/7), 6-2 for her first WTA title since 2016 in Moscow.
The former world number one Maria Sharapova loses first round match with a 6-4 6-4 defeat to Japan's Naomi Osaka at the Indian Wells tennis tournament.
Winners of the men's and women's singles titles will each earn $3.7 million, while runners-up will pocket $1.82 million from the $50.4 million total pot.
For many of the fringe players on the tour, featuring in the first round of a Grand Slam allows them to pick up what could be their biggest pay cheque of the year.
Hobbled by a niggling knee injury, Wawrinka's Wimbledon hopes were shredded by Russian Daniil Medvedev.
Latvia's Jelena Ostapenko won her first Grand Slam after beating world number 3 Simona Halep 4-6 6-4 6-3 at Roland Garros in Paris.
Simona Halep beat Karolina Pliskova 6-4 3-6 6-3 to reach the final. If she wins, the third seed will become world number one.
World number two and defending French Open champion Novak Djokovic was beaten by Dominic Thiem 7-6 (5), 6-3, 6-0, while Rafael Nadal cruised to victory after his opponent retired with an injury.
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