Alcaraz, the first teenager to claim the top ranking, is the youngest Grand Slam men's champion since Rafael Nadal at the 2005 French Open after a performance which yielded 55 winners and 14 aces.
World number one Iga Swiatek downs Tunisia's Ons Jabeur 6-2 7-6(5) to claim her maiden trophy at Flushing Meadows and third Grand Slam title.
The Spaniard had plenty in the tank in his match against Frances Tiafoe, sprinting to drop shots, pounding forehands and coolly holding serve in the tense fifth set.
Fifth seed Ons Jabeur dominates semi-final against Caroline Garcia, winning 6-1, 6-3 in just 1hr 6min. In another semi-final, No. 1-ranked Iga Swiatek beats No. 6 Aryna Sabalenka 3-6, 6-1, 6-4.
A defiant Serena Williams bid an emotional good-bye to the US Open with a third-round loss to Ajla Tomljanovic.
Nadal regrouped and with the backing of the partisan crowd sealed the win on Fognini's 60th unforced error to end the ugly affair in which the players combined for 15 breaks of serve and 11 double faults.
Daniil Medvedev goes on to face Wu Yibing who created a piece of tennis history on Wednesday after becoming the first man from China to reach the third round in New York.
Rafael Nadal triumphed 4-6, 6-2, 6-3, 6-3 over his 198th-ranked Rinky Hijikata to register his 65th career win in New York.
The 23-time Grand Slam winner announced her forthcoming retirement from tennis three weeks ago.
While Nadal trains in New York, career-long rival Djokovic will remain in Europe after finally giving up hope of a last-minute change of Covid policy by the US authorities.
Nadal had not played a competitive match since pulling out of his Wimbledon semi-final against Kyrgios due to injury in early July.
The US tennis great says she is ready to step away from the sport so she can turn her focus to having another child and her business interests.
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