Syrian regime leader Assad and Russia deliver an ultimatum to rebels saying they must accept regime rule or leave the besieged area northeast of Damascus.
The Syrian Observatory for Human Rights says civilians were killed in Douma, the largest town of the opposition-held enclave near Damascus.
At least 45 civilians, including four children killed in rebel-enclave near Damascus on Wednesday by regime air strikes, bringing the death toll in more than two weeks of bombing to 850 civilians.
US-led coalition and Russian air strikes caused mass civilian deaths that may amount to war crimes, say UN investigators in the latest report covering the last six months through to January 15.
A fourth consecutive day of heavy regime bombing raids on the rebel-held enclave of Eastern Ghouta near Damascus has also left more than 100 civilians injured on Thursday, according to the White Helmets.
Amnesty says the regime targeted neighbourhoods 'far away from the front lines and with no apparent military objectives in the vicinity.'
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