The violence in the region of Idlib has forced 520,000 people out of their homes since the start of December, in one of the biggest upheavals in the nine-year civil war.
Since December, intensive aerial bombardment and ground fighting in Idlib, a de-escalation zone, have killed almost 300 civilians and triggered one of the largest waves of displacement in the nine-year war.
Seven of those killed in regime and Russian strikes in Sarmeen town of Idlib province were all members of one family, Syrian Observatory for Human Rights says.
The Britain-based Syrian Observatory for Human Rights, an opposition war monitor, said rebels withdrew from Idlib province's Maarat al Numan town late on Tuesday.
Renewed violence tightened the noose around Syria's last major rebel-held bastion and deepened an already dire humanitarian crisis.
Idlib has come under mounting bombardment in recent weeks, displacing tens of thousands of people in the northwestern province, despite a truce brokered by Turkey and Russia.
A new cessation of hostilities agreement between Russia and Turkey, who support the opposite sides in the conflict, went into effect last week but violence has continued.
Among the dead were four children while 16 others were wounded with some in critical condition, a war monitor says of the attack in the northwestern town, Sarmin.
Pro-Iranian militias in Syria's Deir Ezzor province recently came under missile attacks from unknown launchpads and Tehran did not react to the escalation, indicating the hostility is likely to have wider consequences.
War monitor SOHR says regime push "is an attempt to get closer to Maaret al Numan" in Idlib province which Russia and regime have intensely bombed fuelling exodus of Syrians, many of whom Turkey's President Erdogan says are marching towards Turkey.
Syrian Observatory for Human Rights says eight civilians were killed in the town of Saraqeb while four others were killed in separate air strikes in other towns of southern Idlib.
An intensified bombardment by Russian forces and the Syrian regime has pushed thousands of people to flee to the border with Turkey, residents and rescue workers are saying.
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