With his seventh victory from as many finals at Melbourne Park, the 31-year-old Serb moved past Roger Federer and Roy Emerson, who have six Australian Open titles each.
Britain's former world number one, Andy Murray, has not played since last year's Wimbledon due to a hip injury and subsequent surgery.
World number one tennis player Rafa Nadal says he is not ready to play due to the late start of preparation for the season.
Roger Federer's hopes of claiming a record-extending 20th grand slam title ended when he was beaten 7-5 3-6 7-6(8) 6-4 by Juan Martin del Potro in a thrilling US Open quarter-final.
Venus Williams becomes the oldest player to reach the last 16 at Wimbledon in 23 years as the five-time champion defeated Japan's Naomi Osaka.
Claycourt king Rafa Nadal beat Austrian wonderkid Dominic Thiem 6-3 6-4 6-0 in his comeback to secure a 10th French open title at Roland Garros.
World number two and defending French Open champion Novak Djokovic was beaten by Dominic Thiem 7-6 (5), 6-3, 6-0, while Rafael Nadal cruised to victory after his opponent retired with an injury.
Both men's and women's singles defending champions Novak Djokovic & Garbine Muguruza are through to the next round of the French Open.
Rafael Nadal's victory comes a week after he also won the Monte Carlo Masters for the 10th time.
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