Novak Djokovic sees off Monte Carlo Masters champion Stefanos Tsitsipas to claim the last major tournament before French Open, while Iga Swiatek beats Ons Jabeur to retain the women's title.
The 19-year-old Spaniard reached his second Association of Tennis Professionals Masters final in five weeks and claimed his first win over a reigning world number one, overcoming Djokovic in front of a sell-out home crowd at the Caja Magica.
In a clash of generations, 19-year-old Carlos Alcaraz defeated his idol 6-2, 1-6, 6-3 in the Madrid Open quarterfinals.
Murray has been beset by injury problems in recent years, especially to his hip, and is now ranked 78th in the world.
Simona Halep beats Zhang Shuai 6-2, 6-3 and Paula Badosa defeats Veronika Kudermetova 6-3, 6-0 in the first round.
Rafael Nadal was knocked out of the Madrid Open quarter-finals stage 6-4 6-4 by German Alex Zverev, leaving his No. 2 rank to Daniil Medvedev in the ATP rankings.
Tsitsipas had never won a set in his previous three meetings against claycourt specialist and 11-times French Open champion Nadal, but the Greek drew first blood by saving a break point to hold in the 10th game and take the first set.
The 20-time Grand Slam champion, whose sole French Open title came in 2009, has preferred to skip the European clay season over the last two seasons to manage his schedule.
Austrian Dominic Thiem beat the top-ranked Rafael Nadal 7-5, 6-3 in the Madrid Open quarterfinals on Friday, ending the defending champion's run of 21 straight wins on clay courts.
Canadian tennis player Eugenie Bouchard, who earlier called Maria Sharapova "a cheater", reiterated her stance that the Russian star should not have been allowed to play after she was found guilty of using a performance enhancer.
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