Martina Trevisan, who reached the French Open quarterfinals two years ago as a qualifier, beat Leylah Fernandez 6-2, 6-7 (3), 6-3 to advance to the semis.
Naomi Osaka has struggled for form after withdrawing from French Open in May after a row with tournament officials over required media appearances.
Emma Raducanu has become the youngest Grand Slam champion in 17 years, ending the tournament as the first player since Serena Williams in 2014 to not drop a set in the US Open.
Emma Raducanu, an 18-year-old from Britain who is ranked 150th, and Leykah Fernandez, a 19-year-old from Canada who is ranked 73rd, will clash in first Grand Slam final between teens since 1999.
World number one Ash Barty crashes out of US Open, losing 6-2 1-6 7-6(5) to 43rd-ranked American Shelby Rogers, in biggest upset of tournament thus far.
Naomi Osaka's title defence was over in third round with a 5-7, 6-7 (2), 6-4 loss to Leylah Fernandez, an 18-year-old from Canada who is ranked 73rd and never had been this far in Grand Slam competition.
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