The former Republican senator sees Turkey as an “indispensable ally” and “a bridge” between the West and the turbulent Middle East.
Approved by Senate, former Republican lawmaker replaces outgoing Ambassador David Satterfield.
The nomination of the former Senator, aimed at not rocking the boat any further, comes at a tense time in relations between the two countries.
Flake's appointment comes as Washington tries to mend ties with its Nato ally.
US Congress ends a brief government shutdown by reaching a wide-ranging deal that is expected to push budget deficits into the $1 trillion-a-year zone.
Public criticism from senators Jeff Flake and Bob Corker put additional strain on what is already a fragile relationship between President Trump and fellow Republicans.
Jeff Flake of Arizona declared he would not be "complicit" with US President Donald Trump and announced his surprise retirement, while Bob Corker of Tennessee declared Trump "debases our nation" with constant untruths and name-calling.
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