The crowd in the city's main square appeared to number about 20,000 — though opposition organisers said the number was twice as large and police estimated 6,500 were in attendance.
Among those "neutralised" was senior operative Mehmet Gurbuz who was wanted with a red notice, sources said.
The "bivalent" jab, made by Pfizer/BioNTech, is directed at the highly infectious BA.4 and BA.5 types of the variant.
Turkish President Recep Tayyip Erdogan commented on several foreign policy matters, including energy, Russia, and Greece before starting a three-day tour of the Balkans.
The recent suspension of the EU’s visa deal with Moscow aims to prevent Russian tourists from entering European countries, showing a Western pattern to punish ordinary citizens.
The European Medicines Agency has approved jabs targeting both the original virus and the BA.1 subvariant of Omicron ahead of a feared Covid surge in the latter part of this year.
The EU plans to make it harder for Russians to travel to the bloc by suspending a deal that eases their visa applications, while EU defence ministers consider a military training programme for Ukrainian forces.
The nuclear deal would see sanctions lifted against Iran in exchange for restricting its rapidly advancing nuclear program.
EU foreign policy chief Josep Borrell says Iran gave a reasonable response to the bloc's proposal to revive the 2015 nuclear accord, which he hopes the US will also respond positively to as early as this week.
President Vucic said Belgrade is concerned over the treatment of the Serbian minority in northern Kosovo and called on the Western military alliance for protection.
Kosovo Prime Minister Albin Kurti and Serbian President Aleksandar Vucic take part in the talks chaired by the EU High Representative, who says an agreement has not yet been reached.
The Iranian response has been received and the EU is consulting with the US and the other parties "on the way ahead," a spokesperson for EU foreign policy chief Josep Borrell says.
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