Federer, the defending champion, had chalked up 17 consecutive wins in 2018, including his 20th Grand Slam title at the Australian Open, but was unable to outlast his determined 29-year-old Argentine opponent.
Novak Djokovic beats Donald Young 6-1, 6-2, 6-4 in his first match since Wimbledon as Maria Sharapova has 6-1, 6-4 win over Tatjana Maria following her one-and-half-year ban.
Defending champion Roger Federer will face Slovenian Aljaz Bedene in the first round, while world number one Rafael Nadal takes on Dominican Victor Estrella Burgos.
The former No1-ranked Murray, a three-time major winner, has not played a competitive match since a quarterfinal exit at Wimbledon last July.
After failing to recover from a hip injury, British tennis player Andy Murray withdraws from the season's first Grand Slam, tournament organisers say.
Due to injuries, from "overuse," five of the world's top 11 men's players will miss this year's US Open, which gets under way on Monday. The problem is that the gruelling season is just too much wear and tear on the athletes' bodies.
Murray's absence at the Rogers Cup in Montreal this week means Rafael Nadal could take the top spot should the Spaniard advance to the semi-finals in Canada.
Roger Federer moved into a 12th Wimbledon semi-final and within touching distance of a record eighth title Wednesday as Andy Murray and Novak Djokovic crashed out on a dramatic day at the All England Club.
Nadal fought back from two sets down and saved four match points in a 135-minute minute fifth set in which he successfully served to stay alive nine times, but it was not enough.
Swiss champion and world number 3 Stan Wawrinka prove too strong for world number 1 Andy Murray. The high octane match ended 6-7(6) 6-3 5-7 7-6(3) 6-1.
World number one Andy Murray beat Kei Nishikori 2-6 6-1 7-6(0) setting up a tough semifinal against former French Open Champion Stan Wawrinka who beat Marin Cilic 6-3 6-3 6-1.
Murray will now face Kei Nishikori from Japan, while Stan Warinka will find himself up against Marin Cilic. The victory was Murray's 650th career win.
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