UN Human Rights Council's resolution, adopted with 26 of the council's 47 members in favour, voiced particular concern about the fate of tens of thousands of people who have vanished in the war-ravaged country.
The UN Human Rights Council has called for those behind "massive scale" enforced disappearances in Syria over the past decade of conflict to be held accountable.
The resolution on Tuesday, presented by Britain and a number of European countries, along with the United States, Turkey and Qatar, decried that Syria's crisis had entered a second decade "marked by consistent patterns of gross violations."
The war in Syria has killed nearly 500,000 people since it started in 2011, with all sides in the increasingly complex conflict accused of war crimes.
The resolution, adopted with 26 of the council's 47 members in favour, six opposed and 15 abstaining, voiced particular concern about the fate of tens of thousands of people who have vanished.
'Widespread enforced disappearance'
The text "strongly condemns the continued use of involuntary or enforced disappearances in the Syrian Arab Republic, and related human rights violations and abuses, which have been carried out with consistency, in particular by the Syrian regime."
It also criticised enforced disappearances by other parties to the conflict, including Daesh, but said the Syrian regime was the main perpetrator.
The resolution voiced alarm at recent comments by the UN's independent commission of inquiry on the rights situation in Syria indicating that "widespread enforced disappearance has been deliberately perpetrated by Syrian security forces throughout the past decade on a massive scale."
The investigators had indicated that such disappearances had been used "to spread fear, stifle dissent and as punishment," and that tens of thousands of men, women, boys and girls detained by Syrian authorities "remain forcibly disappeared".
Presenting the resolution to the council, British Ambassador Simon Manley slammed the regime's role in such a massive number of disappearances as "simply inexcusable."
The regime, he said, "has the bureaucratic means to provide information on these disappeared individuals, the means to end the suffering of the families and loved ones of these people."
"But it chooses not to employ those means. This is a deliberate act of unspeakable cruelty."
He echoed a charge in the resolution, accusing Damascus's forces of "intentionally prolonging the suffering of hundreds of thousands of family members."
It emphasised "the need for accountability, including for crimes committed in relation to enforced disappearance," stressing that "accountability is vital in peace negotiations and peace-building processes."