The attack comes a day after several drones attacked the Abha international airport in Saudi Arabia's southwest, prompting Washington to call for an end to Houthi aggression.
Saudi forces have intercepted an armed drone fired by Houthi rebels in Yemen, the Riyadh-led coalition said, a day after a rebel strike on an airport in the kingdom.
The latest drone attack on Thursday targeted the garrison town of Khamis Mushait in southern Saudi Arabia, which hosts a key airbase but was destroyed before reaching its target, coalition spokesperson Turki al Maliki said, quoted by the kingdom's official SPA agency.
Several drones attacked the Abha international airport in the kingdom's southwest on Wednesday, prompting Washington to call for an end to Houthi aggression.
The coalition said the attack set a civilian aircraft ablaze, while the Houthis said they had struck Abha airport with four drones, claiming it was used to launch attacks inside Yemen.
READ MORE: Yemen Houthis say will cease attacks on Saudi if coalition stops
The United Stated reacted by calling for the rebels to "immediately stop these aggressive acts," just days after demanding an end to any new offensive in Yemen.
US President Joe Biden, who has reversed his predecessor Donald Trump's policy on the conflict, has deployed his new Yemen envoy to Saudi Arabia.
Tim Lenderking and his UN counterpart Martin Griffiths met Saudi's deputy defence minister, Khaled bin Salman, who oversees the Yemen portfolio.
US Secretary of State Antony Blinken discussed the attack on Abha during a call with Saudi Foreign Minister Faisal bin Farhan al Saud, SPA reported.
Washington has ended its support for coalition military operations in Yemen and removed the Houthis from a list of designated "terrorist" organisations but reiterated its support for Riyadh in defending its territory.
Britain condemned the attack on Abha, in a Tweet posted by Foreign Secretary Dominic Raab on Thursday.
"We condemn the Houthis' latest attack against Saudi Arabia that hit a civilian plane at Abha Airport. The Houthis must end these outrageous attacks," Raab said.
"The UK is steadfast in its unwavering support for the security of Saudi territory."
READ MORE: US to delist Yemen's Houthis as a terrorist organisation
Battle for Marib
In Yemen itself, the Houthis have resumed an offensive to seize the government's last northern stronghold of Marib.
The battle has centred on a government military base west of the city of Marib, a pro-government commander at the scene told AFP.
"The camp was taken by the Houthis but they were dislodged by aerial raids" by the coalition which struck around 10 times, he said.
Losing the camp would sever an important supply line for government forces, he said.
Clashes at the base on Wednesday killed 23 insurgents and 15 pro-government forces, according to the commander.
Reinforcements to support government forces had arrived in the neighbouring province of Shabwa, he said.
Loudspeakers on mosques in Marib were used to urge locals to join the fight or to donate cash.
READ MORE: Yemen's Houthi rebels move to seize Marib region
The Houthis' self-proclaimed foreign minister, Hisham Sharaf, said on Tuesday that the rebels' cross-border attacks were in response to coalition air raids in support of the government.
The war in Yemen has claimed tens of thousands of lives and displaced millions, according to international organisations, sparking what the UN calls the world's worst humanitarian crisis.
The Houthis are backed by Shia Iran, Sunni Saudi Arabia's arch-rival.
READ MORE: Reports of mass executions in Yemen blamed on Houthis