Israel rarely confirms details of its operations in Syria, but says Iran's presence backing regime leader Bashar al Assad is a threat.
Israeli jets have flown very low over parts of Lebanon, terrifying residents on Christmas Eve, some of whom reported seeing missiles in the skies over Beirut.
Minutes later, Syria's official news agency reported explosions in the central Syrian town of Masyaf in the Hama countryside.
The Syrian Ministry of Defense issued a statement early on Friday saying Israel “launched an aggression by directing a barrage of rockets” from the north of the Lebanese city of Tripoli towards the Masyaf area. It said Syrian air defence “confronted the enemy missiles and intercepted most of them.”
There was no immediate word on what the target was or whether there were any casualties.
Not the first time
Israeli jets regularly violate Lebanese airspace and have often struck inside Syria from Lebanese territory. But the Christmas Eve flights were louder than usual, frightening residents of Beirut who have endured multiple crises in the past year, including the catastrophic August 4 explosion at the city's port that killed over 200 people and destroyed parts of the capital. That explosion resulted from the detonation of a stockpile of ammonium nitrates that was improperly stored at the facility.
There was no immediate word from Israel on Friday's flights and alleged attacks on Syria.
In the past few years, Israel has acknowledged carrying out dozens of airstrikes in Syria, most of them aimed at suspected Iranian weapons shipments believed to be bound for Hezbollah. In recent months, Israeli officials have expressed concern that Hezbollah is trying to establish production facilities to make precision guided missiles.
Masyaf is a significant military area for Syria's Bashar Assad's regime that includes a military academy and a scientific research center. Israel has struck targets there several times in the past.