It is a merger that has has not gone down well, with environmentalists labelling it a "marriage made in hell" promising to focus their protests on Bayer so long as it keeps up the pesticide maker's practices.
Bayer may have finally completed its hard-fought takeover of US seeds and pesticide maker Monsanto, but that is unlikely to silence critics who have dubbed the tie-up a "marriage made in hell".
From fears about the German giant's dominance in global crop production to concerns about the use of genetically modified seeds and harmful weed killers, here's what you need to know about the $63-billion megadeal.
Heroin and Agent Orange
Founded in Germany in 1863, Bayer is still best known for making aspirin. More infamously, it briefly sold heroin in the early 20th century, marketed as cough cure and morphine substitute.
During World War II, Bayer was part of a consortium called IG Farben that made the Zyklon B pesticide used in Adolf Hitler's gas chambers.
Through a series of acquisitions over the years, Bayerhas grown into a drug and chemicals behemoth.
It reported revenues of 35 billion euros ($41 billion) last year and employs nearly 100,000 people worldwide.
Monsanto meanwhile was established in St. Louis, Missouri in 1901, setting out to make saccharine.
By the 1940s, it was producing farm-oriented chemicals, including herbicide 2,4-D which, combined with another dangerous chemical, was used to make the notorious Vietnam War-era defoliant Agent Orange.
In 1976, the company launched probably its best-known product, the weed killer Roundup.
In the 1980s, its scientists were the first to genetically modify a plant cell. Monsanto then started buying other seed companies and began field trials of GM seeds.
It eventually developed soybean, corn, cotton and other crops engineered to be tolerant of Roundup.
Today, Monsanto boasts annual sales of some $15 billion and over 20,000 employees.
A keen suitor
In an industry preparing for a global population surge with billions more mouths to feed, Bayer was keen to get its hands on Monsanto's market-leading line in GM crop seeds designed to resist strong pesticides.
It was also lured by Monsanto's data analytics business Climate Corp, believing farmers will in future rely on digital monitoring of their crops.
The tie-up comes amid a wave of consolidation in the agrochemicals industry, spurring Bayer to become a bigger player if it did not want to get left behind.
But Monsanto wasn't easily wooed, and Bayer had to increase its offer three times before the US rival finally agreed to a deal at $128 per share in 2016.
High price to pay
The takeover, the largest-ever by a German firm, comes at a high cost to Bayer.
As well as the eye-watering price tag, Bayer must give up much of its seeds and agrichemical business to satisfy the competition concerns of global regulators.
Those divestitures have gone to none other than Bayer's homegrown rival BASF, making it the unexpected beneficiary of the mega-deal.
Bayer's sacrifices mean the takeover will be less lucrative than expected, with annual savings now forecast to amount to $1.2 billion from 2022 onwards some 300 million less than initially thought.
Hoping to ditch Monsanto's toxic reputation, Bayer will drop the company's name from its products after the takeover.
Dubbed "Monsatan" and "Mutanto", the US firm has for decades been targeted by environmental groups, especially in Europe, who believe that GM food could be unsafe to eat.
Campaigners also abhor Monsanto's production of glyphosate-based Roundup, which some scientists have linked to cancer.
Friends of the Earth, which has labelled the Bayer-Monsanto merger a "marriage made in hell", said their protests will now be turned on Bayer so long as it keeps up Monsanto's practices.
What does this mean for farmers and consumers?
The Bayer-Monsanto union follows last year's merger of US companies Dow and DuPont and the tie-up between Swiss-based Syngenta and ChemChina.
These three giant corporations now control more than two thirds of the global market for seeds and pesticides although Bayer's sell-offs have allowed BASF to become a sizeable fourth competitor.
While Bayer has been able to ease regulators' worries, critics say too much power is now in the hands of just a few players, potentially pushing up prices for farmers and limiting choices.
Bayer has vowed to continue developing some of Monsanto's most controversial activities, including the crop protection technologies it insists are needed to meet growing food demand.
It has however promised not to introduce GM crops in Europe.