Omicron variant BA.2.75, which has gained ground in India and shows up in several countries, may be able to spread rapidly and get around immunity from vaccines and previous infections, scientists say.
The quickly changing coronavirus has spawned yet another super contagious Omicron mutant that's worrying scientists as it gains ground in India and pops up in numerous other countries, including the United States.
Scientists say the variant – called BA.2.75 – may be able to spread rapidly and get around immunity from vaccines and previous infections. It's unclear whether it could cause more serious disease than other Omicron variants, including the globally prominent BA.5.
"It’s still really early on for us to draw too many conclusions," said Matthew Binnicker, director of clinical virology at the Mayo Clinic in Rochester, Minnesota. "But it does look like, especially in India, the rates of transmission are showing kind of that exponential increase."
Whether it will outcompete BA.5, he said, is yet to be determined.
Still, the fact that it has already been detected in many parts of the world even with lower levels of viral surveillance "is an early indication it is spreading," said Shishi Luo, head of infectious diseases for Helix, a company that supplies viral sequencing information to the US Centers for Disease Control and Prevention.
The latest mutant has been spotted in several distant states in India, and appears to be spreading faster than other variants there, said Lipi Thukral, a scientist at the Council of Scientific and Industrial Research Institute of Genomics and Integrative Biology in New Delhi.
It's also been detected in about 10 other countries, including Australia, Germany, the United Kingdom and Canada.
Two cases were recently identified on the West Coast of the US, and Helix identified a third US case last week.
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Concerns over trajectory of pandemic
Fueling experts' concerns are a large number of mutations separating this new variant from Omicron predecessors.
Some of those mutations are in areas that relate to the spike protein and could allow the virus to bind onto cells more efficiently, Binnicker said.
Another concern is that the genetic tweaks may make it easier for the virus to skirt past antibodies — protective proteins made by the body in response to a vaccine or infection from an earlier variant.
But experts say vaccines and boosters are still the best defence against severe Covid-19.
In the fall it's likely the US will see updated formulations of the vaccine being developed that target more recent Omicron strains.
"Some may say, 'Well, vaccination and boosting hasn't prevented people from getting infected.' And, yes, that is true," he said.
"But what we have seen is that the rates of people ending up in the hospital and dying have significantly decreased. As more people have been vaccinated, boosted or naturally infected, we are starting to see the background levels of immunity worldwide creep up."
It may take several weeks to get a sense of whether the latest Omicron mutant may affect the trajectory of the pandemic.
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