The Pontiff's visit comes at a time when many Chileans are furious over Francis' 2015 decision to appoint a bishop close to Reverend Fernando Karadima, who the Vatican found guilty in 2011 of abusing dozens of minors over decades.
Pope Francis arrived in Chile on Monday to start a trip aimed at bolstering the credibility of a local Church battered by a sexual abuse crisis.
Tens of thousands of people chanting "Viva Papa Francisco" lined the streets of his route from the airport, where he was greeted by President Michelle Bachelet, to the Vatican embassy, his official residence for three days before he moves on to Peru.
Bachelet said on social media shortly after greeting Pope Francis that Chilean society was much changed since the visit of Pope John Paul II in 1987, during the dictatorship of the Augusto Pinochet.
"We are a society more just, more free, and more tolerant," she said, adding, however, that inequality still persisted.
Hundreds of people, many of them children waving Chilean and Vatican flags, greeted Francis outside the Vatican nunciature, or embassy, chanting "Pope Francis, friend, Chile is with you."
TRT World spoke to journalist Laurence Blair on what Pope Francis can expect.
Despite the festive atmosphere, Francis faces protests from Catholics upset with his 2015 appointment of Bishop Juan Barros to head the small diocese of Osorno, a city south of the Chilean capital.
Barros has been accused of protecting his former mentor, Father Fernando Karadima, whom a Vatican investigation in 2011 found guilty of abusing teenage boys over many years. Karadima has denied the allegations and Barros said he was unaware of any wrongdoing.
That scandal, which has gripped Chile, and growing secularisation, has hurt the Church.
On the agenda
A poll by Santiago-based think tank Latinobarometro this month showed that the number of Chileans calling themselves Catholics fell to 45 percent last year, from 74 percent in 1995.
Francis may speak to it and other problems when he makes his first address on Tuesday morning to national authorities and the diplomatic corps.
He then heads to the capital's sprawling Parque O'Higgins, to say a Mass expected to attract more than 500,000 people.
While in Chile, Francis will likely also face protests from indigenous Mapuche who accuse the state and private companies of taking their ancestral land.
Bachelet last year asked for forgiveness from the Mapuche community for such “errors and horrors.”
Francis flies south to Temuco in Chile’s Araucania region, home of the Mapuche, on Wednesday.
Several churches were attacked in the capital last week, including one with a homemade bomb where unidentified vandals left a pamphlet reading "Pope Francis, the next bomb will be in your robe."
No one was injured in the attacks and no one has claimed responsibility.
Shortly before the pontiff's arrival on Monday, a small group of protesters shut down a street in downtown Santiago, but were quickly dispersed by police.
Speaking to reporters aboard the papal plane on the 15-hour flight from Italy, Francis expressed concern about the danger of nuclear war, saying that the world now stood at "the very limit."
His comment came after Hawaii issued a false missile alert that provoked panic in the US state and highlighted the risk of possible unintended nuclear war with North Korea.
Asked if he was worried about the possibility of nuclear war, Pope Francis said: "I think we are at the very limit. I am really afraid of this. One accident is enough to precipitate things."