The US Marine Corps C-130, a refueling plane, crashed on the Sunflower-Leflore county line, US media reports.
A US military aircraft has crashed in the US state of Mississippi, killing at least 16 people, US media reported on Monday.
The US Marine Corps confirmed that a "mishap" involving a KC-130 occurred in the evening, without providing additional details.
The Clarion-Ledger newspaper and CNN cited Leflore County emergency management director Fred Randle as confirming the death toll of 16.
All 16 victims were on the Marine Corps aircraft and there were no survivors, Randle told CNN.
The incident took place around 4:00 pm (2100 GMT), the Clarion-Ledger said, noting that firefighters sprayed the aircraft with huge layers of foam to quell the fire.
The plane crashed in a soybean field on the Sunflower-Leflore county line, the paper said.
Photos posted on its website showed plumes of black smoke billowing from a green agricultural field.
"Please join Deborah and me in praying for those hurting after this tragedy. Our men and women in uniform risk themselves every day to secure our freedom," Mississippi Governor Phil Bryant said in a statement on Facebook.
A Pentagon spokesman separately confirmed only that a Marine Corps aircraft was involved in the incident to which the Marine Corps referred.